• Anker en Anker Advocaten
    Omnipotent
    Leditgrow
    Azarius
  • Announcements

    • karel kweker

      Weedforum.eu petitie   09-02-17

      weedforum.eu cannabisforum voor de recreative blower en medicinale grower, op het forum vind je vele tips and tricks om wietplant te kunnen kweken voor eigen (medicinaal) gebruik. Wij zijn het zat om als criminelen worden gezien, en hebben daarom deze petitie opgezet we hopen dat vele mensen hem zullen tekenen en zullen delen zodat we snel op de benodigde aantal handtekeningen zullen komen.   https://petities.nl/petitions/decriminaliseer-het-kleinschalig-kweken-van-cannabis
elmanito

Pregnenolone Can Protect the Brain from Cannabis Intoxication

1 post in this topic

Pregnenolone is considered the inactive precursor of all steroid hormones, and its potential functional effects have been largely uninvestigated. The administration of the main active principle of Cannabis sativa(marijuana), ∆9-tetrahydrocannabinol (THC), substantially increases the synthesis of pregnenolone in the brain via activation of the type-1 cannabinoid (CB1) receptor. Pregnenolone then, acting as a signaling-specific inhibitor of the CB1 receptor, reduces several effects of THC. This negative feedback mediated by pregnenolone reveals a previously unknown paracrine/autocrine loop protecting the brain from CB1 receptor overactivation that could open an unforeseen approach for the treatment of cannabis intoxication and addiction.

adrenal_pathway.gif


bron

Pregnenolone Can Protect the Brain from Cannabis Intoxication.pdf

Pregnenolone Can Protect the Brain from Cannabis Intoxication1.pdf

Share this post


Link to post
Share on other sites

Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!


Register a new account

Sign in

Already have an account? Sign in here.


Sign In Now